Sedating antihistamines side effects

Low-sedating second-generation medication with fewer adverse effects than first-generation medications. Selectively inhibits peripheral histamine H1 receptors. Available as tab, disintegrating tab (Reditab), syr (5 mg/5 m L), or combined with pseudoephedrine in 12- or 24-h preparations.

AR is characterized by 1 or more of the following symptoms: nasal congestion, rhinorrhea, sneezing, and itching.

Non-sedating antihistamines include rupatidine, which is similar to loratadine.

It is not yet available in New Zealand (December 2018).

Long-acting tricyclic histamine antagonist selective for H1-receptor.

Major metabolite of loratadine, which, after ingestion, is extensively metabolized to active metabolite 3-hydroxydesloratadine.

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Quality-of-life issues associated with AR include sleep disturbance, irritability, depression, productivity loss, slowed psychomotor response times, impaired learning and decision making, and fatigue.

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